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The Role of the Glutamatergic System in the Extinction of Conditioned Reinforcement Processes

NCT00926900 · Status: UNKNOWN · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2011-11-28

No results posted yet for this study

Summary

The aim of this project is to explore whether the extinction of cue-reactivity following a cue-exposure based intervention in volunteers with an alcohol dependence is facilitated by drugs that increase NMDA-receptor function.

It is hypothesised that targeted treatment with D-Cycloserine prior to each extinction training session enhances the effects on cue-reactivity.

Further, a significant correlation between the reduction of cue-reactivity and both reduced craving and relapse probability is expected.

Conditions

  • Alcohol Drinking

Interventions

DRUG

D-cycloserine

50 mg at approximately 1.5 hours prior to cue-exposure training sessions

DRUG

Placebo

Placebo

Sponsors & Collaborators

  • German Research Foundation

    collaborator OTHER

  • Central Institute of Mental Health, Mannheim

    lead OTHER

Principal Investigators

  • Falk Kiefer, Professor · Central Institute of Mental Health, Department of Addictive Behavior and Addiction Medicine

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-03-31
Primary Completion
2012-04-30

Countries

  • Germany

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00926900 on ClinicalTrials.gov