Stress-related Predictor Profiles in Human Addiction

Summary

Long-term aim is the definition of a setup of mobile sensors and their integration in a mobile infrastructure that allows the prediction of stress related alcohol intake in an ambulatory setting. Here, we aim to identify stress- and alcohol cue-related physiological markers in a lab experiment to assess interactions between acute psychological vs. physical stress exposure and alcohol cue-exposure regarding their effects on measures relevant for the development and maintenance of Alcohol Use Disorder (AUD). Further, we aim to identify neural correlates in brain circuits of motivational, cognitive, and affective processing. In addition to applying established stress-related markers, we will integrate innovative sensor-based measures.

Conditions

• Alcohol Use Disorder
• Stress Reaction
• Social Stress
• Craving
• Relapse
• Addiction
• Risk Behavior

Interventions

BEHAVIORAL

Trier Social Stress Test

Test to induce high levels of acute social stress, including actors and a faked exam situation

BEHAVIORAL

Ergometer

Riding ergometer

BEHAVIORAL

Barlab-Exposure

Participants are exposed to a bar situation with different sorts of alcohol available. They sniff at water and at one alcoholic drink.

BEHAVIORAL

Reading Newspaper

Participants read newspaper

Sponsors & Collaborators

• Project Group for Automation in Medicine and Biotechnology PAMB, Mannheim

  collaborator UNKNOWN

• Central Institute of Mental Health, Mannheim

  lead OTHER

Principal Investigators

• Falk Kiefer, Prof. · Central Institute of Mental Health, Mannheim

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-07-01

Primary Completion

2022-09-30

Completion

2023-07-08

Countries

• Germany

Study Locations