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Effect of Ibuprofen, Paracetamol and Their Combination on Radical Oxygen Species (ROS) Production

NCT00921505 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 7

Last updated 2011-07-06

No results posted yet for this study

Summary

The purpose of this study is to determine whether paracetamol, ibuprofen or their combination can modify generation of radical oxygen species (ROS) from stimulated neutrophils.

Conditions

Interventions

DRUG

Ibuprofen

Tablet ibuprofen 400 mg oral single dose (1 tablet)

DRUG

Ibuprofen

Tablets (2 x 600 mg) oral single dose (2 tablets)

DRUG

Paracetamol (acetaminophen) 1000 mg

Tablets (2 x 500 mg) oral single dose (2 tablets)

DRUG

Paracetamol + ibuprofen

Tablets (ibuprofen 400 mg + paracetamol (acetaminophen) 2 x 500 mg) single oral dose (3 tablets)

Sponsors & Collaborators

  • University of Oslo

    collaborator OTHER

  • Ullevaal University Hospital

    lead OTHER

Principal Investigators

  • Torstein Lyberg, DDS, MD · Ullevaal University Hospital

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-05-31
Primary Completion
2010-01-31
Completion
2010-01-31

Countries

  • Norway

Study Locations

More Related Trials

Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00921505 on ClinicalTrials.gov