Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) widely used for pain, inflammation, and fever. It acts primarily by inhibiting cyclooxygenase pathways and reducing prostaglandin synthesis. It was first sold in the United Kingdom in 1969 and in the United States in 1974.
China has become the dominant source of external drug innovation, with pharma licensing deals reaching $135.7 billion in 2025 and China developing 30% of the world's new innovative drugs. Meanwhile, India is expanding AI use in drug discovery and strengthening its CRDMO and IP infrastructure, though investment gaps persist.
Two separate studies examine interventions for individuals affected by preterm birth. A structured exercise program improved cardiovascular health and blood pressure in young adults born preterm. Meanwhile, prophylactic acetaminophen given to extremely preterm infants did not improve survival without severe morbidity, despite accelerating closure of a common heart defect.
Pivya (pivmecillinam) is now available in the US for treating uncomplicated urinary tract infections in adult female patients, based on three phase 3 trials showing efficacy against susceptible bacterial isolates.
Recent studies reveal significant barriers in accessing mental health care for children and maternal health services, with nearly 25% of children's mental health needs going unmet and abortion restrictions linked to increased maternal deaths.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07766330 |
Effect of Nonsteroidal Anti-Inflammatory Drug Restriction on the Efficacy of Platelet-Rich Plasma in Knee Osteoarthritis |
NOT_YET_RECRUITING | NA |
| NCT07732751 |
Botulinum Toxin Type A Versus Oral Ibuprofen for Bruxism |
COMPLETED | PHASE4 |
| NCT07682558 |
Efficacy of Non-opioid Drugs in Addition to Opioid Therapy for Cancer Pain Management |
NOT_YET_RECRUITING | PHASE3 |
| NCT07644065 |
Kynurenic Acid and Serotonin as Perioperative Neuroinflammatory Biomarkers in Sequential Third Molar Surgery |
COMPLETED | NA |
| NCT07618494 |
Elevation of Effect of Common Analgesic on Pulp Sensibility Tet |
COMPLETED | NA |
| NCT07603934 |
The Effect of Different Intra-canal Medications on Postoperative Pain |
RECRUITING | EARLY_PHASE1 |
| NCT07571252 |
Impact of Preemptive Analgesia on Postoperative Pain in Orthognathic Surgery |
NOT_YET_RECRUITING | PHASE4 |
| NCT07565012 |
Comparative Evaluation of Diclofenac Sodium and Ibuprofen for Post-Endodontic Pain Management |
COMPLETED | PHASE4 |
| NCT07533721 |
Ibuprofen vs Expectant Management for hsPDA in Preterm Infants: Retrospective Cohort |
COMPLETED | |
| NCT07401927 |
Preemptive Analgesia in Laparoscopic Hysterectomy |
COMPLETED |
