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Analgesic Effect of Paracetamol, Paracetamol + Codeine, Ibuprofen and Their Combination

NCT00921700 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 200

Last updated 2016-03-30

No results posted yet for this study

Summary

The purpose of this study is to determine whether the combination of paracetamol (acetaminophen) and other NSAIDs with or without weak opioids can give synergistic analgesic effect.

Conditions

  • Pain, Postoperative

Interventions

DRUG

Ibuprofen + Paracetamol

Single oral dose of ibuprofen 400 mg combined with paracetamol (acetaminophen) 1000 mg in gelatine capsules

DRUG

Ibuprofen + Paracetamol + Codeine

Single oral dose of ibuprofen 400 mg combined with paracetamol (acetaminophen) 1000 mg and codeine 60 mg in gelatine capsules

DRUG

Paracetamol + Codeine

Single oral dose of paracetamol (acetaminophen) 1000 mg combined with codeine 60 mg in gelatine capsules

DRUG

Placebo

Single oral dose of lactose as placebo in gelatine capsules

Sponsors & Collaborators

  • University of Oslo

    collaborator OTHER

  • Ullevaal University Hospital

    lead OTHER

Principal Investigators

  • Lasse A Skoglund, DDS, DSci · University of Oslo

  • Gaute Lyngstad, DDS · University of Oslo

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-06-30
Primary Completion
2014-11-30
Completion
2015-04-30

Countries

  • Norway

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00921700 on ClinicalTrials.gov