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Ibuprofen and Opioid (Morphine or Diamorphine) for Acute Pain in Sickle Cell Disease - Sickle With Ibuprofen & Morphine

NCT00880373 · Status: TERMINATED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 320

Last updated 2012-12-04

No results posted yet for this study

Summary

The use of oral ibuprofen combined with Opioid (Morphine or Diamorphine) administered through patient controlled analgesia (PCA) will be clinically effective for acute pain crisis in adults with sickle cell disease (SCD).

Conditions

Interventions

DRUG

Ibuprofen

Oral ibuprofen 800 mg three times daily for a total of 2400 mg per day for 4 days

DRUG

Placebo

Matching placebo three times daily for 4 days

DRUG

Diamorphine or Morphine

Diamorphine or Morphine by PCA

Sponsors & Collaborators

  • Medical Research Council CTU

    collaborator UNKNOWN

  • London North West Healthcare NHS Trust

    lead OTHER

Principal Investigators

  • Kofi A Anie, PhD · London North West Healthcare NHS Trust

  • Gavin Cho, MD · London North West Healthcare NHS Trust

  • Mark Layton, MD · Imperial College London

  • Sarah Meredith, MD · MRC Clinical Trials Unit

  • Caroline Dore, BSc · MRC Clinical Trials Unit

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-03-31
Primary Completion
2014-03-31
Completion
2014-08-31

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00880373 on ClinicalTrials.gov