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Nutritional Intervention for Age-related Muscular Function and Strength Losses

NCT00874575 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 76

Last updated 2014-09-17

No results posted yet for this study

Summary

The purpose of the study is to

* Test the effect of a dietary supplement beta-hydroxy-beta-methylbutyrate (HMB) with and without Vitamin D to prevent and reverse the losses of muscular strength and functionality in older adults.

The second aim of the study is to determine if HMB and Vitamin D improves markers of bone turnover in adults aged 60 plus years. HMB is a dietary supplement that comes from the amino acid leucine. HMB is found in foods and is made in your body after you eat protein (meat). Subjects will be randomized to one of four dietary supplement groups and will participate in a 3-day per week exercise program for 12 weeks. Each exercise day will be about 60 minutes long consisting of strength training exercises utilizing Theraband® stretch cords and jumping.

Subjects will consume the dietary supplement 2 times per day for 12 weeks. Tests will consist of the following:

* Measuring the strength of subjects' legs by using a Isokinetic Dynamometer
* Measuring body composition
* Measuring hand-grip strength using a hand-grip dynamometer
* Measuring functional mobility, balance and agility by the time it takes for you to rise from a chair, walk around a cone 8 feet in front of the chair and return to the chair (Up-\&-Go Test
* Filling out questionnaires and having blood drawn for biochemical measurements. Testing will be performed at the beginning and at 4, 8 and 12 weeks.

Conditions

Interventions

DRUG

Beta-hydroxy-Beta-methylbutyrate and Vitamin D

DIETARY_SUPPLEMENT

Placebo

DIETARY_SUPPLEMENT

Vitamin D

DIETARY_SUPPLEMENT

Beta-hydroxy-Beta-methylbutyrate

Sponsors & Collaborators

  • Iowa State University

    collaborator OTHER

  • South Dakota State University

    collaborator OTHER

  • Metabolic Technologies Inc.

    lead INDUSTRY

Principal Investigators

  • John A. Rathmacher, Ph.D. · Metabolic Technologies

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
FACTORIAL

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-11-30
Primary Completion
2013-07-31
Completion
2013-07-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00874575 on ClinicalTrials.gov