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Vitamin D for Muscle Metabolic Function in Cancer Cachexia

NCT03144128 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1

Last updated 2020-10-14

No results posted yet for this study

Summary

The proposed study is aimed at examining mitochondrial function as a potential target of action of vitamin D on muscle metabolism, size, and strength in preventing the progression of cachexia. This is the first clinical trial designed to understand the effects of vitamin D on muscle metabolic dynamics driving dysfunction in cachectic muscle. Our preliminary data suggest that vitamin D promotes lipid partitioning and muscle metabolic function, which the investigators hypothesize, will mitigate cachexia via improved muscle health and quality that translates into reduced fatigue, and improved patient resilience to multimodal cancer therapy.

Conditions

  • Cancer Cachexia
  • Vitamin D Deficiency

Interventions

DIETARY_SUPPLEMENT

Vitamin D

5,000IU vitamin D given daily for 12 weeks

DIETARY_SUPPLEMENT

Placebo

Placebo capsules given daily for 12 weeks

Sponsors & Collaborators

  • David Travis Thomas

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
45 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-05-23
Primary Completion
2018-09-13
Completion
2018-09-13

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03144128 on ClinicalTrials.gov