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Urinary Cytokine Levels as a Prognostic Marker for Kidney Scarring After Pyelonephritis

NCT00868270 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 35

Last updated 2009-03-24

No results posted yet for this study

Summary

The prevalence of kidney scarring after UTI is approximately 5-57%. UTIs are caused mainly by bacteria that cause local and systemic immunological reaction that are accompanied by cytokines. These cytokines are a main factor in the inflammatory process. They are produced by leukocytes, macrophages, fibroblasts, endothelial cells and epithelial cells in the kidney tissue. Interleukin 6 and 8 (IL-6 IL-8) were found in high levels in the urine of children and adults who suffer from UTIs. Other studies on animals have found a relationship between inflammatory reaction and scarring in the kidney. We hypothesize that we will find a similar relationship between the level of IL-6, IL-8 in the urine during acute pyelonephritis in children and the probability of kidney scarring.

Conditions

  • Kidney Scarring Post-Febrile UTI

Sponsors & Collaborators

  • Hillel Yaffe Medical Center

    lead OTHER_GOV

Eligibility

Max Age
7 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-05-31

Countries

  • Israel

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00868270 on ClinicalTrials.gov