Study of Genetic Anomalies of Complement Related Proteins in Patients With IgA Glomerulonephritis
NCT00004305 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 105
Last updated 2005-06-24
Summary
OBJECTIVES: I. Determine whether allelic differences associated with the fourth component of complement, type-1 complement receptor expressed on erythrocytes, and Fc receptor FcgRIII contribute to the pathogenesis of IgA glomerulonephritis (IgA-N).
II. Compare genetic anomalies of these key components in immune complex processing and clearance between juvenile vs adult onset IgA-N vs normal controls.
Conditions
- IGA Glomerulonephritis
Sponsors & Collaborators
-
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
collaborator NIH -
Ohio State University
collaborator OTHER -
National Center for Research Resources (NCRR)
lead NIH
Principal Investigators
-
Lee A. Hebert · Ohio State University
Eligibility
- Min Age
- 0 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 1998-01-31
Countries
- United States
Study Locations
More Related Trials
-
An Observational Study of IgA Nephropathy: Pathological Variants and Clinical Data
NCT01502579 ·Status: COMPLETED
-
Pathogenesis of Glomerulosclerosis
NCT00001392 ·Status: COMPLETED
-
Immune System and Gut Abnormalities in Patients With Common Variable Immunodeficiency With and Without Gastrointestinal Symptoms
NCT00015431 ·Status: COMPLETED
-
Interest of Follicular Helper Lymphocytes / Regulatory Follicular Helper Lymphocytes Ratio in IgA Nephropathy
NCT05791162 ·Status: RECRUITING ·Phase: NA
-
Non-Invasive Assessment of Atherosclerosis in Patients With CGD and Other Disorders of the Immune System
NCT01063309 ·Status: COMPLETED
-
Multicenter Study Evaluating the Performance of the Assay of Anti-hinge Region Antibodies in the Diagnosis of Progressive Forms of IgA Nephropathy
NCT02526966 ·Status: COMPLETED ·Phase: NA
-
IgA-positive Versus IgA-negative Immune Complex Vasculitis
NCT01815190 ·Status: UNKNOWN
-
Detection and Characterization of Host Defense Defects
NCT00001355 ·Status: RECRUITING
-
Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic Vasculitis
NCT02257866 ·Status: RECRUITING
-
Pilot Study of Gut Commensals in Antiphospholipid Syndrome
NCT01787305 ·Status: ACTIVE_NOT_RECRUITING
-
Immune Dysregulation in Hepatitis C Patients With or Without Arthritis
NCT01195987 ·Status: UNKNOWN
-
Angiotensin-Converting Enzyme Gene Polymorphism and the Risk of Chronic Allograft Nephropathy
NCT00006328 ·Status: COMPLETED
-
A Study to Assess the Effects of Zigakibart on IgA Nephropathy.
NCT07146906 ·Status: RECRUITING ·Phase: PHASE2
-
Biomarkers for the Progression of IgA Nephropathy
NCT02529722 ·Status: COMPLETED
-
Evaluation and Long-Term Follow-up of Patients With Inflammatory Disorders
NCT00001351 ·Status: ENROLLING_BY_INVITATION
-
Retrospective Study for Diagnosis of Undetected IgG4 Related Diseases in Patients With High Serum IgG4 Levels.
NCT02229448 ·Status: COMPLETED
-
Polymorphism of the IgH Locus Regulatory Region as a Prognostic Factor During Immune Pathologies.
NCT01715623 ·Status: COMPLETED
-
Discovery and Validation of Proteogenomic Biomarker Panels in Liver Transplant Recipients
NCT01672164 ·Status: COMPLETED
-
Impaired Type I IFN Immunity Due to Autoantibodies or a Genetic Defect: a Prospective National Cohort
NCT06762002 ·Status: RECRUITING
-
Inflammatory Responses in Normal Volunteers and Patients With Abnormal Immune Responses
NCT00001257 ·Status: TERMINATED
-
IgA Nephropathy, Lymphocyte Homing and IgA Class Switch
NCT01775527 ·Status: COMPLETED ·Phase: NA
-
Evaluation of Patients With Immune Function Abnormalities
NCT00128973 ·Status: RECRUITING
-
RESistance of IgA Nephropathy to Conventional and Newly-approved Therapies: an Observational, Real-life Study (RESIGAN)
NCT06926244 ·Status: RECRUITING
-
Unclassified GENotypes of Autoinflammatory Diseases and AA Amyloidosis
NCT06354322 ·Status: RECRUITING
-
IgA Nephropathy Biomarkers Evaluation Study (INTEREST)
NCT02954419 ·Status: RECRUITING