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Vitamin D Supplementation During Pregnancy for Prevention of Asthma in Childhood

NCT00856947 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 600

Last updated 2026-03-19

No results posted yet for this study

Summary

The aim of this study is to prevent asthma symptoms (recurrent wheeze) in childhood by supplementation with high dose vitamin D to the mother during pregnancy. Participants are mothers and children of the ABC (Asthma Begins in Childhood) cohort. Mothers are recruited during pregnancy and receive daily supplement with 2400 IU of Vitamin D3 or placebo from week 24 og gestation to 1 week after delivery. In addition all mothers are advised to take the recommended dose of 400 IU vitamin D daily. The mothers in ABC also participate in an interventional trial with fish oil supplementation, and the vitamin D randomization is stratified by fish oil treatment group. The child is followed with acute and planned vits at the research unit, and wheeze is diagnosed according to predefined algorithms.

Conditions

Interventions

DIETARY_SUPPLEMENT

Cholecalciferol D3

2 tablets of 1200 IU daily from week 24 of gestation to 1 week after delivery

OTHER

Placebo tablet

2 tablets containing no active substance

Sponsors & Collaborators

  • Copenhagen Studies on Asthma in Childhood

    lead OTHER

Principal Investigators

  • Klaus Bønnelykke, MD, PhD · Copenhagen Studies on Asthma in Childhood

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-03-31
Primary Completion
2027-07-31
Completion
2027-07-31

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00856947 on ClinicalTrials.gov