MedTrace Logo

Methylation of p16 CpG Island And Malignant Transformation of Oral Epithelial Dysplasia

NCT00835341 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 93

Last updated 2015-06-01

Study results available
· View outcomes & findings →

Summary

Oral epithelial dysplasia (OED) is one of the common precancerous lesions among Chinese adults. Biomarker is not available for detection of malignant potential of OED till now. p16 is an important tumor suppressor gene, which is inactivated frequently by methylation of CpG island in early stage of carcinogenesis. The present cohort study is to investigate whether p16 methylation is correlated with malignant transformation of OED.

Conditions

  • Oral Epithelial Dysplasia, Mild or Moderate Grade

Sponsors & Collaborators

  • Peking University

    lead OTHER

Principal Investigators

  • Dajun Deng, MD · Beijing Cancer Hospital/ Institue, Peking University School of Oncology

  • Hongwei Liu, MD, PhD · Peking University School of Stomatology

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2005-03-31
Primary Completion
2008-10-31
Completion
2008-10-31

Countries

  • China

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00835341 on ClinicalTrials.gov