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Metabolic Causes of Thrombosis in Type 2 Diabetes Mellitus

NCT00829699 · Status: COMPLETED · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 31

Last updated 2019-09-12

No results posted yet for this study

Summary

The purpose of this study is to learn more about why patients with diabetes have increased heart attacks, strokes and other illnesses due to blood clots causing blockage of a blood vessel. The proposed protocol will study the separate and combined effects of high glucose and high fats on certain cardiovascular responses in Type 2 DM.

Conditions

Interventions

PROCEDURE

euinsulinemic euglycemic glucose clamp

euinsulinemic euglycemic glucose clamp with lipid infusion 48 ml/hr for 4 hours

PROCEDURE

euinsulinemic hyperglycemic glucose clamp

euinsulinemic hyperglycemic glucose clamp with lipid infusion at 48 ml/hr for 4 hours

PROCEDURE

Hyperinsulinemic euglycemic glucose clamp

Hyperinsulinemic euglycemic glucose clamp with lipid infusion at 48 ml/hr for 4 hours

PROCEDURE

Hyperinsulinemic hyperglycemic glucose clamp

Hyperinsulinemic hyperglycemic glucose clamp with lipid infusion at 48 ml/hr for 4 hours

Sponsors & Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • University of Maryland, Baltimore

    lead OTHER

Principal Investigators

  • Stephen N. Davis, MD · University of Maryland, Baltimore

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
FACTORIAL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-07-31
Primary Completion
2013-06-30
Completion
2014-04-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00829699 on ClinicalTrials.gov