Cardiopulmonary Exercise Testing and Preoperative Risk Stratification

Summary

The investigators would like to evaluate the use of cardiopulmonary exercise tests (CPX) in guiding the care pathway of patients undergoing colorectal operations. In the intervention group care will be guided by CPX results and in the control group care will be guided by the doctors assessment. The investigators would like to assess the impact of this on patient outcome, patient satisfaction and resource usage.

Conditions

• Colorectal Cancer
• Anaesthesia
• Critical Illness

Interventions

OTHER

Perioperative care pathway guided by CPX results

* AT \> 11ml/min/kg no myocardial ischaemia or Ve/VO2 \<35 - Level 1 Ward Care * AT \> 11ml/min/kg with myocardial ischaemia or Ve/VO2 \>35 - Level 2/3 (ITU) Critical Care Unit * AT \<11mls/min/kg - Level 2/3 Critical Care Unit * AT \<8mls/min/kg - Level 2/3 Critical Care Unit/ consider cancellation or alternative procedure

Sponsors & Collaborators

• University Hospital Southampton NHS Foundation Trust

  collaborator OTHER

• University College London Hospitals

  lead OTHER

Principal Investigators

• Michael PW Grocott · University College, London

• Paula Meale · University College, London

• Michael Mythen · University College, London

• Ayo Oshowo · Whittington Hospital NHS Trust

• Mervyn Singer · University College, London

• Geoff Bellingan · University College London Hospitals

• Kay Mitchell · University College, London

• Hasan Muktar · The Whittington Hospital Hospital NHS Trust

• Alistair Windsor · University College London Hospitals

• Jim Down · University College London Hospitals

• Martin B Kuper · Whittington Hospital NHS Trust

• Denny ZH Levett · University College, London

• Phil Hennis, PhD · UCL

• Alasdair O'Doherty, MSc · UCL

• Alec Engledow · UCLH

• Aundrea Mulreany · Whittington Hospital

• Carolyn Dr Way · University Hospital Southampton NHS Foundation Trust

• Karen Linford · University Hospital Southampton NHS Foundation Trust

• Clare Bolger · University Hospital Southampton NHS Foundation Trust

• Paul Nichols · University Hospital Southampton NHS Foundation Trust

• Kim Golder · University Hospital Southampton NHS Foundation Trust

• John S Knight · University Hospital Southampton NHS Foundation Trust

• Michael Celinski · University Hospital Southampton NHS Foundation Trust

• Grace Adesina · University College London Hospitals

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2008-08-31

Primary Completion

2013-06-30

Completion

2014-05-31

Countries

• United Kingdom

Study Locations