First-Line Combination Chemotherapy in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery
NCT00736814 · Status: UNKNOWN · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 117
Last updated 2011-02-24
Summary
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. It is not yet known which combination chemotherapy regimen is most effective in treating non-small cell lung cancer.
PURPOSE: This randomized phase II trial is comparing different combination chemotherapy regimens to see how well they work as first-line therapy in treating patients with stage IIIB or stage IV non-small cell lung cancer that cannot be removed by surgery.
Conditions
Interventions
- DRUG
-
Given intravenously
- DRUG
-
Given intravenously
- DRUG
-
gemcitabine hydrochloride
Given intravenously
- DRUG
-
vinorelbine tartrate
Given intravenously
Sponsors & Collaborators
-
Yonsei University
lead OTHER
Principal Investigators
-
Byung Chul Cho · Yonsei University
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2008-06-30
Countries
- South Korea
Study Locations
More Related Trials
-
Random Trial for Elderly Patients With NSCLC
NCT00265694 ·Status: UNKNOWN ·Phase: PHASE3
-
A Study of Tarceva (Erlotinib) in Combination With Platinum Based Chemotherapy in Patients With Non-Small Cell Lung Cancer.
NCT01998919 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy and Radiation Therapy in Treating Patients With Stage III Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery
NCT00616785 ·Status: UNKNOWN ·Phase: PHASE2
-
S9806: Combination Chemotherapy in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer
NCT00003587 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy in Treating Patients With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer
NCT00054392 ·Status: WITHDRAWN ·Phase: PHASE3
-
Gemcitabine Hydrochloride and Carboplatin With or Without MK-0646 as First-Line Therapy in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer
NCT00951444 ·Status: WITHDRAWN ·Phase: PHASE2
-
Gemcitabine and Carboplatin Followed By Docetaxel in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer
NCT00074204 ·Status: COMPLETED ·Phase: PHASE3
-
Chemotherapy or Observation in Treating Patients With Early Stage Non-Small Cell Lung Cancer
NCT00863512 ·Status: TERMINATED ·Phase: PHASE3
-
Ph II Gemcitabine, Erlotinib, and Gemcitabine With Erlotinib/Elderly Patients W/ IIIB/IV NSCLC
NCT00283244 ·Status: COMPLETED ·Phase: PHASE2
-
Carboplatin and Paclitaxel With or Without Vorinostat in Treating Patients With Advanced Non-Small Cell Lung Cancer
NCT01413750 ·Status: TERMINATED ·Phase: PHASE2
-
Comparison of Two Combination Chemotherapy Regimens in Treating Non-small Cell Lung Cancer
NCT00006004 ·Status: COMPLETED ·Phase: PHASE2
-
Chemotherapy in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer
NCT00004100 ·Status: UNKNOWN ·Phase: PHASE3
-
Vinorelbine/Gemcitabine Versus Vinorelbine/Carboplatin in Advanced Non-small Cell Lung Cancer
NCT00737867 ·Status: COMPLETED ·Phase: PHASE3
-
Vorinostat, Carboplatin, and Paclitaxel in Treating Patients With Advanced or Metastatic Non-Small Cell Lung Cancer
NCT00481078 ·Status: COMPLETED ·Phase: PHASE2
-
Gemcitabine, Carboplatin, and Bortezomib in Advanced or Recurrent Non-Small Cell Lung Cancer
NCT00075751 ·Status: COMPLETED ·Phase: PHASE2
-
Gemcitabine and Docetaxel in Treating Patients With Inoperable Stage IIIB or Stage IV Non-Small Cell Lung Cancer
NCT00075517 ·Status: UNKNOWN ·Phase: PHASE2
-
A Phase II Trial of Genexol-PM and Gemcitabine in Patients With Advanced Non-small-cell Lung Cancer
NCT01770795 ·Status: COMPLETED ·Phase: PHASE2
-
Paclitaxel/Carboplatin (PC) Followed by Gefitinib Versus PC in Advanced Non-small Cell Lung Cancer
NCT01196234 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase 2 Trial of Antisense Nucleotide to PKC-Alpha (LY900003, ISIS 3521) Plus Gemcitabine and Carboplatin in Patients With Advanced, Previously Untreated Non-Small Cell Lung Cancer.
NCT00042679 ·Status: COMPLETED ·Phase: PHASE2
-
Reduced CT + Anti-PD-1 as First Line Tx in Vulnerable Older Adults w/Adv <50% PD-L1 Non-Small Cell Lung Cancer (NSCLC)
NCT06731413 ·Status: RECRUITING ·Phase: PHASE2
-
Combination Chemotherapy in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer
NCT00004209 ·Status: UNKNOWN ·Phase: PHASE3
-
Efficacy Trial of Gemcitabine Containing Regimens As Preoperative Chemotherapy in Non Small Cell Lung Cancer
NCT00191256 ·Status: COMPLETED ·Phase: PHASE2
-
Pilot Study for the Determination of Tumor Response to Chemotherapy in Advanced NSCLC Through Gene Expression Profiling
NCT00161278 ·Status: TERMINATED ·Phase: PHASE2
-
A Phase II Clinical Trial of Docetaxel, Oxaliplatin Combination Chemotherapy in Patients With Stage IIIB/IV Non-adenocarcinoma, Non-small Cell Lung Cancer (NSCLC) as Second-line Treatment
NCT01497041 ·Status: UNKNOWN ·Phase: PHASE2
-
Paclitaxel and Carboplatin Chemotherapy Compared With Standard Chemotherapy in Treating Patients With Stage III or Stage IV Non-small Cell Lung Cancer That Cannot Be Removed During Surgery
NCT00004887 ·Status: UNKNOWN ·Phase: PHASE3