Low-Dose Aspirin in in Vitro Fertilization (IVF) and Intracytoplasmic Sperm Injection (ICSI) Treatments

Summary

In this study we hypothesized that low-dose aspirin therapy (100 mg daily) improves ovarian responsiveness, uterine haemodynamics and clinical pregnancy rates in unselected subjects undergoing IVF/ICSI when the treatment is started concomitantly with controlled ovarian hyperstimulation.

Conditions

• Pregnancy
• Miscarriage Less Than 12 Gestational Weeks
• Extrauterine Pregnancy
• Preeclampsia
• Intrauterine Fetal Growth Restriction

Interventions

DRUG

Acetylsalicylic acid

Acetylsalicylic acid 100 mg or placebo daily perorally started on the first day of ovarian gonadotrophin stimulation in in vitro fertilization or in intracytoplasmic sperm injection

DRUG

Placebo

Acetylsalicylic acid 100 mg or placebo daily perorally started on the first day of ovarian gonadotrophin stimulation in in vitro fertilization or in intracytoplasmic sperm injection

Sponsors & Collaborators

• Bayer

  collaborator INDUSTRY

• Kuopio University Hospital

  collaborator OTHER

• Tampere University

  collaborator OTHER

• University of Oulu

  lead OTHER

Principal Investigators

• Mervi Haapsamo, MD · University Hospital of Oulu, Finland

• Juha Rasanen, MD · University Hospital of Oulu, Finland and Oregon Health Sciences University, Oregon USA

• Hannu Martikainen, MD · University Hospital of Oulu, Finland

• Juha S Tapanainen, Prof · University Hospital of Oulu, Finland

• Seppo Heinonen, Prof · University Hospital of Kuopio, Finland

• Helena Tinkanen, MD · Unversity Hospital of Tampere, Finland

Study Design

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

39 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2001-03-31

Primary Completion

2006-03-31

Completion

2006-03-31

Countries

• Finland

Study Locations