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The Effect of Laser Assisted Hatching in Thawing Cycles: a Prospective Randomized Controlled Study

NCT00593775 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 647

Last updated 2017-05-02

No results posted yet for this study

Summary

The successful hatching process is a prerequisite for implantation. Freezing/thawing cycles can impair the hatching process by introducing changes in the composition of the zona pellucida. The purpose of this study is to test the hypothesis that the implantation rate per embryo and the clinical pregnancy rate per embryo transfer is higher after embryo transfer of frozen-thawed embryos with opened or thinned ZP after assisted hatching when compared to embryo transfer of frozen-thawed embryos without assisted hatching.

All patients starting a thawing cycle (with frozen embryos on d1-d2-d3-d5) can be included in this RTC study. Assisted hatching will be performed with a non-contact 1.48 diode laser system (MTG, Germany).

Conditions

  • Placenta; Implantation

Interventions

PROCEDURE

assisted hatching

assisted hatching with laser

Sponsors & Collaborators

  • KU Leuven

    lead OTHER

Principal Investigators

  • Thomas M D'Hooghe, MD · UZ Leuven

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
47 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-02-28
Primary Completion
2008-07-31
Completion
2008-07-31

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00593775 on ClinicalTrials.gov