Fludeoxyglucose F 18-PET/CT Imaging in Assessing Response to Chemotherapy in Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Hodgkin Lymphoma
NCT00678327 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 1202
Last updated 2024-05-08
Summary
RATIONALE: Imaging procedures, such as fludeoxyglucose F 18 (FDG)-PET/CT scan, done before, during, and after chemotherapy may help doctors assess a patient's response to treatment and help plan the best treatment. It is not yet known whether FDG-PET/CT imaging is effective in assessing response to chemotherapy in patients with newly diagnosed Hodgkin lymphoma.
PURPOSE: This randomized phase III trial is studying FDG-PET/CT imaging to see how well it works in assessing response to chemotherapy in patients with newly diagnosed stage II, stage III, or stage IV Hodgkin lymphoma.
Conditions
Interventions
- BIOLOGICAL
-
bleomycin sulfate
Given IV
- BIOLOGICAL
-
Given subcutaneously
- BIOLOGICAL
-
Given subcutaneously
- DRUG
-
Given IV
- DRUG
-
dacarbazine
Given IV
- DRUG
-
doxorubicin hydrochloride
Given IV
- DRUG
-
etoposide
Given IV
- DRUG
-
prednisolone
Given orally
- DRUG
-
procarbazine hydrochloride
Given orally
- DRUG
-
vinblastine sulfate
Given IV
- DRUG
-
vincristine sulfate
Given IV
Sponsors & Collaborators
- collaborator OTHER
-
Cancer Research UK & UCL Cancer Trials Centre
collaborator OTHER -
University College, London
lead OTHER
Principal Investigators
-
Peter Johnson, MD · University Hospital Southampton NHS Foundation Trust
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 100 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2008-08-29
- Primary Completion
- 2016-01-31
- Completion
- 2024-05-01
Countries
- United Kingdom
Study Locations
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