Positron Emission Tomography and Computed Tomography in Guiding Radiation Therapy for Stage III Non-small Cell Lung Cancer
NCT01507428 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 138
Last updated 2026-04-21
Summary
This randomized phase II trial studies how well positron emission tomography (PET)/computed tomography (CT)-guided radiation therapy works compared to standard radiation therapy in treating patients with stage III non-small cell lung cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Using imaging procedures, such as PET and CT scans, to guide the radiation therapy, may help doctors deliver higher doses directly to the tumor and cause less damage to healthy tissue.
Conditions
- Stage III Lung Non-Small Cell Cancer AJCC v7
- Stage IIIA Lung Non-Small Cell Cancer AJCC v7
- Stage IIIB Lung Non-Small Cell Cancer AJCC v7
Interventions
- RADIATION
-
Image-Guided Adaptive Radiation Therapy
Undergo individualized adaptive radiotherapy
- OTHER
-
Laboratory Biomarker Analysis
Correlative studies
- DRUG
-
Given IV
- PROCEDURE
-
Positron Emission Tomography
Undergo FDG PET/CT
- PROCEDURE
-
Positron Emission Tomography
Undergo FMISO PET/CT (Correlative studies)
- DRUG
-
Fludeoxyglucose F-18
Undergo FDG PET/CT
- DRUG
-
18F-Fluoromisonidazole
Undergo FMISO PET/CT (Correlative studies)
- DRUG
-
Given IV
- PROCEDURE
-
Computed Tomography
Undergo FDG PET/CT
- PROCEDURE
-
Computed Tomography
Undergo FMISO PET/CT (Correlative studies)
- RADIATION
-
External Beam Radiation Therapy
Undergo radiotherapy
Sponsors & Collaborators
- collaborator OTHER
-
National Cancer Institute (NCI)
lead NIH
Principal Investigators
-
Feng-Ming (Spring) P Kong · NRG Oncology
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2012-02-22
- Primary Completion
- 2020-08-17
- Completion
- 2022-05-20
Countries
- United States
- Canada
Study Locations
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