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Oxidative Stress and Endothelial Dysfunction in Obstructive Sleep Apnea

NCT00646971 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 11

Last updated 2010-07-12

No results posted yet for this study

Summary

Patients with sleep apnea syndrome have repeated apneic events that induce periodic hypoxia-reoxygenation, drawing away an overproduction of oxidants. This exaggerated generation of oxidants is associated with a dysfunction of the vascular endothelium that evolves, in its turn, towards cardiovascular diseases such as systemic hypertension, stroke, and myocardial infarction. The major aim of our study is to examine the effect of CPAP treatment on biochemical (markers of oxidative stress) and functional (endothelium-dependent vascular relaxation reactivity) abnormalities at 1 and 4 weeks of treatment.

Conditions

  • Obstructive Sleep Apnea Syndrome
  • Endothelial Dysfunction
  • Oxidative Stress
  • Intermittent Hypoxia
  • Cardiovascular Risk

Interventions

DEVICE

CPAP device

for 4 weeks

DEVICE

Placebo device

for 4 weeks

Sponsors & Collaborators

  • Assistance Publique - Hôpitaux de Paris

    lead OTHER

Principal Investigators

  • Pierre ESCOURROU, MD, PhD · Assistance Publique - Hôpitaux de Paris Hôpital Antoine Béclère

  • Gabriel ROISMAN, MD, PhD · Assistance Publique - Hôpitaux de Paris, Hôpital Antoine Béclère

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-01-31
Primary Completion
2010-04-30
Completion
2010-04-30

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00646971 on ClinicalTrials.gov