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Endothelial Dysfunction, Monocyte Activation, and Vasculopathy in Patients With Obstructive Sleep Apnea (OSA) and Effect of 6-month CPAP Treatment

NCT01312168 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 150

Last updated 2016-12-14

No results posted yet for this study

Summary

This purpose of this study is to

1. Determine the change in endothelial dependent vascular reactivity and vascular properties
2. Determine the changes in monocytes activation
3. Determine the change in pro-inflammatory status
4. Investigate the effect of six-month CPAP therapy on the above changes in patients with OSA

Conditions

  • Sleep Apnea, Obstructive
  • Continuous Positive Airway Pressure
  • Endothelium
  • Inflammation
  • Vascular Function

Interventions

DEVICE

Therapeutic CPAP

CPAP ventilator, optimal pressure decided by CPAP manual titration, daily use at sleep, six months

DEVICE

Subtherapeutic CPAP

Subtherapeutic CPAP ventilator, pressure \<3 cmH2O, daily use at sleep, six months

Sponsors & Collaborators

  • China Medical University, China

    collaborator OTHER

  • National Taiwan University Hospital

    lead OTHER

Principal Investigators

  • Peilin Lee, M.D. · National Taiwan University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
65 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-03-31
Primary Completion
2017-02-28
Completion
2017-02-28

Countries

  • Taiwan

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01312168 on ClinicalTrials.gov