Impact of Fluid Restriction Policy in Reducing the Use of Red Cells in Cardiac Surgery

Summary

The investigators' hypothesis is that restriction of circulating fluids in comparison to a liberal fluid administration policy would lead to a reduction of allogenic red blood cells exposure in patients undergoing cardiopulmonary bypass (CPB) for primary coronary artery bypass graft supported by reinfusion of washed shed blood from thoracic cavities.

Conditions

• Coronary Artery Disease
• Coronary Artery Bypass
• Erythrocyte Transfusion

Interventions

PROCEDURE

Fluid Restriction Policy

Infusion of Hes 130/0.4 up to 500 ml until the beginning of Cardiopulmonary bypass

PROCEDURE

Free fluid infusion

Free fluid infusion unless Hb\< 6g/dl(allogenic blood use), until the beginning of Cardiopulmonary bypass

Sponsors & Collaborators

• Larissa University Hospital

  lead OTHER

Principal Investigators

• ATHINA KLEITSAKI, Dr · Larissa University Hospital

• GEORGE VRETZAKIS, M.D. PhD · Cardiac Anesthesia Unit, Department of Anesthesiology, University Hospital of Larissa, Greece

• KONSTANTINOS STAMOULIS, M.D. · Cardiac Anesthesia Unit, Department of Anesthesiology, University Hospital of Larissa, Greece

• CHRISTOS DRAGOUMANIS, M.D. PhD · Cardiac Anesthesia Unit, Department of Anesthesiology, University Hospital of Larissa, Greece

• VASILIOS TASOUDIS, M.D. · Cardiac Anesthesia Unit, Department of Anesthesiology, University Hospital of Larissa, Greece

• KATERINA KYRIAKAKI, M.D. · Cardiac Anesthesia Unit, Department of Anesthesiology, University Hospital of Larissa, Greece

• DEMETRIOS MIKROULIS, M.D. PhD · Department of Cardiothoracic Surgery, University Hospital of Larissa, Greece

• ATHANASIOS GIANNOUKAS, MD MSc PhD · Department of Vascular Surgery, University Hospital of Larissa, Greece

• NIKOLAOS TSILIMINGAS, M.D. PhD · Department of Cardiothoracic Surgery, University Hospital of Larissa, Greece

Study Design

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Model

PARALLEL

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2007-11-30

Primary Completion

2008-11-30

Completion

2011-03-31

Countries

• Greece

Study Locations