Estrogen, Diet, Genetics and Endometrial Cancer

Summary

The purpose of this study is to see how people's diets, other aspects of their lifestyles, and their individual genetic makeup affect their chances of getting endometrial cancer (cancer of the uterus).

This survey will enroll several hundred women who have or have had endometrial cancer and several hundred who do not. We will compare these two groups of women to see what factors may lead to endometrial cancer.

Conditions

• Cancer
• Endometrial Cancer
• Ovarian Cancer
• Corpus Uteri
• Endometrium

Interventions

BEHAVIORAL

Questionnaire

The main questionnaire will cover established risk and protective factors for endometrial and ovarian cancer, as well as other possible risk factors. This includes: menstrual history; pregnancy history; use of hormones for menopausal symptoms or other reasons; smoking history; height and weight; use of oral contraceptives and other methods of birth control; family history of cancer; medical history; demographic characteristics. We will also collect dietary data using the Gladys Block questionnaire, to which we have added a supplement to measure consumption of phytoestrogens. We will also obtain a buccal sample from each respondent as the source of DNA for genetic analysis.

BEHAVIORAL

Questionnaire

The main questionnaire will cover established risk and protective factors for endometrial and ovarian cancer, as well as other possible risk factors. This includes: menstrual history; pregnancy history; use of hormones for menopausal symptoms or other reasons; smoking history; height and weight; use of oral contraceptives and other methods of birth control; family history of cancer; medical history; demographic characteristics. We will also collect dietary data using the Gladys Block questionnaire, to which we have added a supplement to measure consumption of phytoestrogens. We will also obtain a buccal sample from each respondent as the source of DNA for genetic analysis. We will conduct interviews mainly by telephone but also in person (at home or another convenient place)if the participant prefers.

Sponsors & Collaborators

• National Cancer Institute (NCI)

  collaborator NIH

• Rutgers Cancer Institute of New Jersey

  collaborator OTHER

• Municipal Institute of Medical Research

  collaborator UNKNOWN

• Department of Health and Human Services

  collaborator FED

• Penn State University

  collaborator OTHER

• Memorial Sloan Kettering Cancer Center

  lead OTHER

Principal Investigators

• Mengmeng Du, ScD · Memorial Sloan Kettering Cancer Center

Eligibility

Min Age

21 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2001-09-25

Primary Completion

2026-12-31

Completion

2026-12-31

Countries

• United States

Study Locations