Vaccine Therapy With or Without Cryosurgery in Treating Patients With Residual, Relapsed, or Refractory B-Cell Non-Hodgkin Lymphoma

Summary

RATIONALE: Vaccines, such as dendritic cell therapy (DC) made from a person's tumor cells and white blood cells may help the body build an effective immune response to kill tumor cells. Cryosurgery kills cancer cells by freezing them. Giving vaccine therapy together with cryosurgery may kill more tumor cells. PURPOSE: This clinical trial studies giving vaccine therapy together with or without cryosurgery in treating patients with B-cell Non-Hodgkin's lymphoma.

Conditions

• Cutaneous B-cell Non-Hodgkin Lymphoma
• Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue
• Nodal Marginal Zone B-cell Lymphoma
• Adult Diffuse Mixed Cell Lymphoma
• Adult Diffuse Small Cleaved Cell Lymphoma
• Adult Grade III Lymphomatoid Granulomatosis
• Adult Immunoblastic Large Cell Lymphoma
• Adult Lymphoblastic Lymphoma
• Grade 1 Follicular Lymphoma
• Grade 2 Follicular Lymphoma
• Grade 3 Follicular Lymphoma
• Mantle Cell Lymphoma
• Marginal Zone Lymphoma
• Small Lymphocytic Lymphoma
• Splenic Marginal Zone Lymphoma
• Waldenstrom Macroglobulinemia With Nodal Disease

Interventions

BIOLOGICAL

dendritic cell vaccine therapy

Given intratumorally

PROCEDURE

cryotherapy

Undergo cryoablation

BIOLOGICAL

pneumococcal polyvalent vaccine

Given intramuscularly

OTHER

laboratory biomarker analysis

Correlative studies

OTHER

immunoenzyme technique

Correlative studies

OTHER

immunohistochemistry staining method

Correlative studies

BIOLOGICAL

autologous dendritic cell-tumor fusion vaccine

Given intradermally

Sponsors & Collaborators

• National Cancer Institute (NCI)

  collaborator NIH

• Mayo Clinic

  lead OTHER

Principal Investigators

• Yi Lin, M.D. · Mayo Clinic

Study Design

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

90 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2010-11-30

Primary Completion

2015-11-24

Completion

2019-07-17

Countries

• United States

Study Locations