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Regulation of Fat-stimulated Neurotensin Secretion in Healthy Subjects

NCT00541762 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 34

Last updated 2015-03-10

No results posted yet for this study

Summary

Context: Cholecystokinin (CCK) and neurotensin are stimulated during meal intake by the presence of fat in the small intestine. The sequence of events suggests that fat hydrolysis is crucial for triggering the release.

Objectives: The aim of this study was therefore to investigate whether CCK mediated the effect of intraduodenal (ID) fat on neurotensin secretion via CCK-1 receptors.

Conditions

  • Healthy

Interventions

DIETARY_SUPPLEMENT

Fat perfusion to the small intestine

1. Triglycerides, long chain fatty acids, medium chain fatty acids perfused to the small intestine 2. Orlistat perfused to the small intestine 3. DEXLOX as CCK-1 receptor antagonist

Sponsors & Collaborators

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Juergen Drewe, MD · University Hospital, 4031 Basel, Switzerland

  • Christoph Beglinger, MD · Department of Research and Clinical Pharmacology, University Hospital, Basel Switzerland

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-01-31
Primary Completion
2007-03-31
Completion
2007-03-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00541762 on ClinicalTrials.gov