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Examining Cognitive Function and Brain Abnormalities in Adults With Sickle Cell Disease

NCT00528801 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 212

Last updated 2017-03-21

Study results available
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Summary

Sickle cell disease (SCD), also known as sickle cell anemia, is an inherited blood disease that can cause intense pain episodes and may lead to organ failure. Preliminary studies have shown that adults with SCD may have brain abnormalities that contribute to problems with cognitive functioning, including attention and memory difficulties. This study will use brain magnetic resonance imaging (MRI) and neuropsychological testing to examine the differences in cognitive functioning in adults with SCD and adults without SCD.

212 subjects participated in this cross-sectional study consisting of screening questionnaires, a neuropsychological testing battery, and MRI testing. Enrollment into this study ended in May 2008.

Conditions

  • Anemia, Sickle Cell

Interventions

BEHAVIORAL

NP Battery

Neuropsych Battery with 7 different tests that evaluate the patients neurological functioning.

PROCEDURE

MRI

The MRI is a standard procedure involving 30 minutes under the machine in order to obtain various images of the patients brain.

Sponsors & Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • UCSF Benioff Children's Hospital Oakland

    lead OTHER

Principal Investigators

  • Elliott Vichinsky, MD · Northern California CSCC (Children's Hospital Oakland)

Eligibility

Min Age
21 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2004-12-31
Primary Completion
2008-05-31
Completion
2008-05-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00528801 on ClinicalTrials.gov