Sickle Cell Disease (SCD) Bone Pain Study

Summary

A prospective study to determine how low bone mineral density and/or vertebral compression fractures associate with pain in adults with sickle cell disease

Conditions

• Sickle Cell Disease
• Sickle Cell Anemia
• Low Bone Density
• Osteoporosis
• Osteopenia
• Vertebral Fracture
• Vertebral Compression
• Osteonecrosis
• Ischemic Necrosis
• Avascular Necrosis

Interventions

OTHER

Dual-energy X-ray absorptiometry

Measure bone mineral density at the lumbar spine, left total hip, left forearm, and whole body

OTHER

Vertebral fracture analysis

Obtain thoracolumbar morphometry in DXA scan, then determine presence and severity of vertebral compression fractures by VFA

OTHER

Adult Sickle Cell Quality of Life Measurement System pain impact questionnaire

Calculate patient-reported total pain scores to determine the pain phenotype of each study participant

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI)

  collaborator NIH

• Doris Duke Charitable Foundation

  collaborator OTHER

• University of California, Davis

  lead OTHER

Principal Investigators

• Oyebimpe O Adesina, MD, MS · UC Davis School of Medicine

Study Design

Allocation

NA

Purpose

SCREENING

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-11-03

Primary Completion

2024-04-30

Completion

2026-07-31

Countries

• United States

Study Locations