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Neurovascular Determinants of Cognitive Function in Adults With Sickle Cell Disease

NCT02946905 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 226

Last updated 2023-05-01

No results posted yet for this study

Summary

Cognitive impairment is a poorly understood, serious, and emerging complication for adult patients with sickle cell disease. Because there is extensive microvascular damage from oxidative damage in sickle cell disease, the investigators hypothesize that this is also present in the cerebral microvasculature to cause cognitive impairment. The investigators plan to test this by correlating markers of inflammation and oxidative damage with cognitive performance and 7 Tesla brain MRI microvascular findings in these patients, with the long term goal of understanding the mechanisms and risk factors of cognitive impairment in sickle cell disease.

Conditions

Sponsors & Collaborators

  • University of Pittsburgh

    lead OTHER

Principal Investigators

  • Enrico Novelli, MD · University of Pittsburgh

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-04-30
Primary Completion
2023-03-31
Completion
2023-03-31

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02946905 on ClinicalTrials.gov