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Effect of Enalapril Plus Folic Acid on Blood Pressure and Glycometabolism

NCT00520247 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 443

Last updated 2007-08-23

No results posted yet for this study

Summary

Combinded therapy with folic acid and enalapril may significantly decrease plasma total homocysteine level and had beneficial effect on blood pressure reduction and glycometabolism.

Conditions

  • Plasma Total Homocysteine Level
  • Blood Pressure

Interventions

DRUG

enalapril plus folic acid

enalapril 10.0 mg daily for 8 weeks (the control group); enalapril 10.0 mg plus folic acid 0.4 mg daily for 8 weeks (Low-dose group); enalapril 10.0 mg plus folic acid 0.8 mg daily for 8 weeks (High-dose group)

Sponsors & Collaborators

  • Peking University First Hospital

    collaborator OTHER

  • Huashan Hospital

    collaborator OTHER

  • Harbin Medical University

    collaborator OTHER

  • China Medical University Hospital

    collaborator OTHER

  • First Affiliated Hospital Xi'an Jiaotong University

    collaborator OTHER

  • Nanjing Medical University

    collaborator OTHER

  • Anhui Medical University

    lead OTHER

Principal Investigators

  • Ping Liu, Dr. · Peking University First Hopital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
28 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2005-09-30
Completion
2006-02-28

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00520247 on ClinicalTrials.gov