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Transfusion Triggers in Cardiac Surgery

NCT00470444 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2015-07-31

No results posted yet for this study

Summary

A high proportion of patients having cardiac surgery receive red cell transfusions. Yet, the investigators do not know whether transfusions are beneficial and they may be associated with harm. It is thus important to determine when a transfusion is required. The investigators will conduct a small pilot study at St. Michael's Hospital to address this issue. Patients having cardiac surgery will be allocated to one of two transfusion strategies with endpoints being compliance with the transfusion strategy and clinical outcome. The results of this study will be used to design a large definitive multicentered trial of these two transfusion strategies.

Conditions

  • Cardiac Surgery

Interventions

PROCEDURE

Transfusion with Red Blood Cells

Units of donated Red blood cells

BIOLOGICAL

1 unit of donated red blood cells

Units of red blood cells

BIOLOGICAL

1 unit of donated red blood cells

Units of donated red blood cells

Sponsors & Collaborators

  • Canadian Blood Services

    collaborator OTHER

  • Unity Health Toronto

    lead OTHER

Principal Investigators

  • David Mazer, MD · St. Michael's Hospital, University of Toronto

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-12-31
Primary Completion
2009-04-30
Completion
2009-05-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00470444 on ClinicalTrials.gov