S0424 - Carcinogens in Lung Tissue From Smokers (Closed to Entry as of 7/15/07) and Non-Smokers With Newly Diagnosed Stage I, Stage II, or Stage III Non-Small Cell Lung Cancer
NCT00450281 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 981
Last updated 2015-10-26
Summary
RATIONALE: Studying samples of blood and tissue from smokers (closed to entry as of 7/15/07) and non-smokers with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors learn more about risk factors for lung cancer and may help the study of cancer in the future.
PURPOSE: This clinical trial is studying carcinogens in lung tissue from smokers (closed to entry as of 7/15/07) and non-smokers with newly diagnosed stage I, stage II, or stage III non-small cell lung cancer.
Conditions
Interventions
- GENETIC
-
chromogenic in situ hybridization
- GENETIC
-
gene expression analysis
- GENETIC
-
mutation analysis
- GENETIC
-
polymerase chain reaction
- GENETIC
-
polymorphism analysis
- OTHER
-
fluorescent antibody technique
- OTHER
-
immunohistochemistry staining method
- OTHER
-
laboratory biomarker analysis
- OTHER
-
matrix-assisted laser desorption/ionization time of flight mass spectrometry
- OTHER
-
study of socioeconomic and demographic variables
- PROCEDURE
-
study of high risk factors
Sponsors & Collaborators
-
National Cancer Institute (NCI)
collaborator NIH -
SWOG Cancer Research Network
lead NETWORK
Principal Investigators
-
Christine B. Ambrosone, PhD · Roswell Park Cancer Institute
-
Regina M. Santella, PhD · Herbert Irving Comprehensive Cancer Center
-
Kathy S. Albain, MD · Loyola University
-
Paul H. Gumerlock, PhD · University of California, Davis
Eligibility
- Min Age
- 18 Years
- Max Age
- 120 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2005-10-31
- Primary Completion
- 2012-07-31
- Completion
- 2012-07-31
Countries
- United States
Study Locations
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