Randomised Ischaemic Mitral Evaluation (RIME) Trial

Summary

The study is a randomised controlled trial comparing two treatment strategies for patients with moderate functional ischaemic mitral regurgitation undergoing coronary artery bypass grafting (CABG). Patients will be randomised to receive either CABG alone or CABG plus mitral annuloplasty. The objective of the study is to determine if mitral annuloplasty in addition to CABG improves outcome in patients with moderate functional ischaemic mitral regurgitation.

Conditions

• Mitral Regurgitation
• Coronary Artery Disease

Interventions

PROCEDURE

CABG + Mitral valve annuloplasty

Patients will receive a mitral annuloplasty ring in addition to coronary artery bypass grafting.

PROCEDURE

CABG

Patients will undergo coronary artery bypass grafting alone.

Sponsors & Collaborators

• Department of Health, United Kingdom

  collaborator OTHER_GOV

• British Heart Foundation

  collaborator OTHER

• British Medical Association

  collaborator OTHER

• Royal Brompton & Harefield NHS Foundation Trust

  collaborator OTHER

• Imperial College Healthcare NHS Trust

  collaborator OTHER

• University Hospitals, Leicester

  collaborator OTHER

• Medical University of Silesia

  collaborator OTHER

• University Hospitals Bristol and Weston NHS Foundation Trust

  collaborator OTHER

• Blackpool Victoria Hospital

  collaborator OTHER

• Imperial College London

  lead OTHER

Principal Investigators

• John R Pepper, MChir, FRCS · Royal Brompton & Harefield NHS Foundation Trust

• Marcus Flather, MBBS, FRCP · Royal Brompton Hospital NHS Trust, London

• K. M. John Chan, FRCS CTh · Royal Brompton Hospital NHS Trust, London

Study Design

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Model

PARALLEL

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2007-01-31

Primary Completion

2012-04-30

Completion

2012-08-31

Countries

• Poland
• United Kingdom

Study Locations