Transcatheter Treatment for Combined Aortic and Mitral Valve Disease. The Aortic+Mitral TRAnsCatheter (AMTRAC) Valve Registry

Summary

an international multicentre registry designed to answer 3 clinical questions:

1. Describing the characteristics and outcomes of current patients undergoing aortic + mitral transcatheter heart valve procedures.
2. Better understanding of the predictors for MR regression following isolated TAVI and consequently estimating the fraction of patients who will be suitable for TMVR/r post TAVI
3. Examining the clinical outcomes of patients with significant MR post TAVI who subsequently underwent TMVR/r compared to those left for medical management.

Conditions

• Aortic Stenosis
• Mitral Regurgitation

Interventions

DEVICE

TAVI

Trascatheter aortic valve implantation

DEVICE

TMVR/r

Transcatheter mitral valve replacement/repair

Sponsors & Collaborators

• Clinique Pasteur

  collaborator OTHER

• University of Catania

  collaborator OTHER

• Montefiore Medical Center

  collaborator OTHER

• University Medical Centre Ljubljana

  collaborator OTHER

• University of Bonn

  collaborator OTHER

• Medical University of Vienna

  collaborator OTHER

• University Hospital, Antwerp

  collaborator OTHER

• University of Padova

  collaborator OTHER

• Erasmus Medical Center

  collaborator OTHER

• Clinical Institute Saint Ambrogio, Milan

  collaborator UNKNOWN

• Hospital San Carlos, Madrid

  collaborator OTHER

• McGill University

  collaborator OTHER

• Mayo Clinic

  collaborator OTHER

• IRCCS San Raffaele

  collaborator OTHER

• IRCCS Policlinico S. Donato

  collaborator OTHER

• Galway University Hospitals

  collaborator UNKNOWN

• Tel-Aviv Sourasky Medical Center

  collaborator OTHER_GOV

• University Hospital Freiburg

  collaborator OTHER

• Hadassah Medical Organization

  collaborator OTHER

• Insel Gruppe AG, University Hospital Bern

  collaborator OTHER

• Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

  collaborator OTHER

• Teikyo University

  collaborator OTHER

• Rigshospitalet, Denmark

  collaborator OTHER

• Cliniche Humanitas Gavazzeni

  collaborator OTHER

• G. Pasquinucci Heart Hospital, Massa

  collaborator OTHER

• Aarhus University Hospital

  collaborator OTHER

• Royal Victoria Hospital, Belfast

  collaborator OTHER

• University of British Columbia

  collaborator OTHER

• Cardiovascular Center Frankfurt

  collaborator OTHER

• Rabin Medical Center

  lead OTHER

Principal Investigators

• Ran Kornowski, MD · Rabin Medical Center

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-09-01

Primary Completion

2020-09-01

Completion

2020-12-31

FDA Device

Yes

Countries

• Israel

Study Locations