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Effectiveness of Two Types of Treatment in Restoring Muscle After Hip or Knee Surgery

NCT00393848 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2014-06-02

Study results available
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Summary

The purpose of this study is to determine the effects of two postoperative interventions designed to preserve muscle protein after major hip or knee surgery.

Conditions

Interventions

DRUG

Essential amino acid supplement

15g of essential amino acid in capsule form three times daily during hospitalization, continued through 6 weeks after discharge.

DRUG

Ketoconazole

200mg ketoconazole twice daily; started night before surgery and continued through hospitalization.

DRUG

Placebo

Placebo for Ketoconazole

Sponsors & Collaborators

  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

    collaborator NIH

  • University of Arkansas

    lead OTHER

Principal Investigators

  • Arny Ferrando, PhD · University of Arkansas

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-10-31
Primary Completion
2012-10-31
Completion
2012-10-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00393848 on ClinicalTrials.gov