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Comparing Vasopressin and Adrenaline in Patients With Cardiac Arrest

NCT00358579 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 727

Last updated 2017-03-17

Study results available
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Summary

The effectiveness of medications in cardiac arrest has been greatly debated and questioned. Historically intravenous adrenaline has been the drug of choice since 1906. There have been few formal evaluations to determine the value of adrenaline for cardiac arrest, and clinical trials have not been able to show any benefit with intravenous adrenaline (compared to placebo or no treatment) in the field.

Thus the purpose of this study is to compare vasopressin and adrenaline in the treatment of cardiac arrest to answer the question whether there is an improvement in survival between vasopressin and adrenaline.

Conditions

  • Cardiac Arrest

Interventions

DRUG

Adrenaline

1 mg

DRUG

Vasopressin

40 IU

Sponsors & Collaborators

  • National Medical Research Council (NMRC), Singapore

    collaborator OTHER_GOV

  • Alexandra Hospital

    collaborator OTHER

  • National University Hospital, Singapore

    collaborator OTHER

  • Changi General Hospital

    collaborator OTHER

  • Singapore General Hospital

    lead OTHER

Principal Investigators

  • Marcus EH Ong, MBBS · Singapore General Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
17 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-03-31
Primary Completion
2009-01-31
Completion
2010-01-31

Countries

  • Singapore

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00358579 on ClinicalTrials.gov