Pharmacology of Cognition in Schizotypal Personality Disorder
NCT00353379 · Status: TERMINATED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 29
Last updated 2017-02-10
Summary
This study will determine the effectiveness of guanfacine in improving cognitive and functional impairments in schizotypal personality disorder.
Conditions
- Schizotypal Personality Disorder
- Personality Disorders
Interventions
- DRUG
-
Guanfacine
Participants will take guanfacine for 6 weeks. Guanfacine dosages will not exceed 2 mg per day.
- DRUG
-
Participants will take placebo for 6 weeks.
Sponsors & Collaborators
-
National Institute of Mental Health (NIMH)
collaborator NIH -
Icahn School of Medicine at Mount Sinai
lead OTHER
Principal Investigators
-
Larry J. Siever, MD · Bronx VA Medical Center/Icahn School of Medicine at Mount Sinai
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- DOUBLE
- Model
- CROSSOVER
Eligibility
- Min Age
- 18 Years
- Max Age
- 60 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 1995-09-30
- Primary Completion
- 1997-05-31
- Completion
- 1997-05-31
Countries
- United States
Study Locations
More Related Trials
-
Pergolide for Cognitive Symptoms in Schizotypal Personality Disorder
NCT00252044 ·Status: UNKNOWN ·Phase: NA
-
A Study to Evaluate the Safety and Efficacy of Clozapine in Patients With Treatment-resistant Schizophrenia
NCT00250575 ·Status: COMPLETED ·Phase: PHASE3
-
Cognitive Effects of Nimodipine in Patients With Schizophrenia
NCT03671525 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Clozapine Versus Chlorpromazine for Treatment-Unresponsive Schizophrenia
NCT00169039 ·Status: TERMINATED ·Phase: PHASE4
-
A Study Of Adjunctive Treatment Of Cognitive Deficits In Schizophrenia
NCT00567203 ·Status: COMPLETED ·Phase: PHASE1
-
Treatment Response to Rehabilitation in Patients With Schizophrenia
NCT00063336 ·Status: COMPLETED ·Phase: NA
-
Clinical Testing of a D1 Agonist for Cognitive Enhancement in Schizotypal Personality Disorder
NCT01466205 ·Status: UNKNOWN ·Phase: PHASE2
-
Assessing the Effects of Fanapt® on Social Cognition in Schizophrenia
NCT01929889 ·Status: TERMINATED ·Phase: PHASE4
-
The Effect of a Six Week Intensified Pharmacological Treatment for Schizophrenia Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.
NCT05958875 ·Status: RECRUITING ·Phase: PHASE4
-
Treatment Study for Cognitive Deficits in Schizophrenia
NCT00505076 ·Status: COMPLETED ·Phase: PHASE2
-
Therapeutic Drug Monitoring for Individualized Clozapine Therapy
NCT03523741 ·Status: UNKNOWN
-
The Phase I Study of HS-10509 in Chinese Adult Subjects
NCT06301074 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
MK0557 for the Treatment of Cognitive Impairment in Patients With Schizophrenia (0557-027)
NCT00482430 ·Status: COMPLETED ·Phase: PHASE2
-
Use of Galantamine and CDP-choline (Citicoline) to Treat Adults With Schizophrenia
NCT00509067 ·Status: COMPLETED ·Phase: PHASE2
-
Biomarker Strategies for Medication-Enhanced Cognitive Training in Schizophrenia
NCT01555697 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Effect of AQW051 on Cognitive Function in Patients With Chronic Stable Schizophrenia
NCT01163227 ·Status: COMPLETED ·Phase: PHASE2
-
Effect of MMFS-202-302 on Cognitive Enhancement in Schizophrenia
NCT02237235 ·Status: COMPLETED ·Phase: PHASE2
-
Serotonin 1A Agonists and Cognition in Schizophrenia
NCT00178971 ·Status: COMPLETED ·Phase: PHASE3
-
Translational Neuroscience Optimization of GlyT1 Inhibitor
NCT01911676 ·Status: COMPLETED ·Phase: PHASE2
-
Response to Clozapine in Treatment Resistant Schizophrenia: A Longitudinal Magnetic Resonance Spectroscopy Study
NCT02714894 ·Status: UNKNOWN
-
Effectiveness of an Interactive Educational Website for Improving the Quality of Mental Health Care for People With Schizophrenia
NCT00312949 ·Status: COMPLETED ·Phase: NA
-
Pharmacologic Augmentation of Targeted Cognitive Training in Schizophrenia
NCT04414930 ·Status: COMPLETED ·Phase: PHASE2
-
Tryptophan-Kynurenine Pathway Metabolism in the Pathophysiology of Cognitive Impairment in Schizophrenia.
NCT07162467 ·Status: ENROLLING_BY_INVITATION
-
Cognitive Therapy for Negative Symptoms and Functioning
NCT00350883 ·Status: COMPLETED ·Phase: PHASE2
-
Study to Evaluate the Efficacy and Safety of GSK239512 in Schizophrenia
NCT01009060 ·Status: COMPLETED ·Phase: PHASE2