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Randomized Trial of Two Antimalarial Treatments for Clearing Low Density P.Falciparum Parasitaemia in Sudan

NCT00330902 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 104

Last updated 2007-10-31

No results posted yet for this study

Summary

In areas of seasonal malaria transmission, treatment of carriers of malaria parasites, whose parasitaemia persists at very low levels throughout the dry season, could be a useful strategy for malaria control in areas with a short transmission season. We did a randomized trial to compare two regimens for clearance of low level parasitaemia in the dry season.

Conditions

  • Plasmodium Infections

Interventions

DRUG

sulfadoxine-pyrimethamine (SP) plus artesunate (AS)

sulfadoxine-pyrimethamine (SP) plus three daily doses of artesunate (AS)

DRUG

primaquine (PQ) plus SP+AS

single dose of primaquine on day 4

Sponsors & Collaborators

  • Tropical Medicine Research Institute

    collaborator OTHER

  • World Health Organization

    collaborator OTHER

  • London School of Hygiene and Tropical Medicine

    lead OTHER

Principal Investigators

  • Badria B El Sayed, PhD · TMRI, Khartoum

  • Omer Z Baraka, MD · Faculty of Medicine, University of Khartoum

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
3 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2004-01-31
Completion
2004-11-30

Countries

  • Sudan

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00330902 on ClinicalTrials.gov