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Comparative Evaluation of the Safety and the Efficacy of 2 Antimalarials Depending on HIV Status

NCT00304980 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 3000

Last updated 2010-09-14

No results posted yet for this study

Summary

The purpose of this study is to determine the safety and efficacy of sulfadoxine-pyrimethamine (SP) versus artemether-lumefantrine (Coartem) when administered to HIV+ and HIV- patients with uncomplicated P. falciparum malaria. Patients will be randomised to one of the 2 treatment and followed up (until day 14 actively) for 45 days.

Conditions

  • Plasmodium Falciparum Malaria

Interventions

DRUG

ARTEMETHER + LUMEFANTRINE VS. SULFADOXINE + PYRIMETHAMINE

Sponsors & Collaborators

  • Institute of Tropical Medicine, Belgium

    lead OTHER

Principal Investigators

  • Umberto D'Alessandro, MD,MSc, PHD · Institute of Tropical Medicine Antwerp

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
15 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2003-03-31
Completion
2005-04-30

Countries

  • Zambia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00304980 on ClinicalTrials.gov