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Effect of Antimalarial Treatment on Gametocyte Carriage in Asymptomatic P. Falciparum

NCT00289250 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 360

Last updated 2006-03-01

No results posted yet for this study

Summary

Treatment of uncomplicated P.falciparum malaria with sulfadoxine-pyrimethamine (SP) is followed by a marked increase in the density of gametocytes. To determine whether treatment with SP enhances gametocyte carriage, we randomized asymptomatic carriers of P.falciparum to receive SP alone, SP with a single dose of artesunate, or placebo, and followed them for 56 days to record gametocyte presence and density.

Conditions

  • Asymptomatic P.Falciparum Malaria

Interventions

DRUG

Sulfadoxine-pyrimethamine

DRUG

Sulfadoxine-pyrimethamine plus artesunate

Sponsors & Collaborators

  • Medical Research Council Unit, The Gambia

    collaborator OTHER

  • London School of Hygiene and Tropical Medicine

    lead OTHER

Principal Investigators

  • Margaret Pinder, PhD · Medical Research Council Unit, The Gambia

  • Paul J Milligan, PhD · London School of Hygiene and Tropical Medicine

  • Sam K Dunyo, PhD · Medical Research Council Unit, The Gambia

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
6 Months
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2001-05-31
Completion
2001-12-31

Countries

  • The Gambia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00289250 on ClinicalTrials.gov