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Exercise to Treat Depression in Individuals With Coronary Heart Disease

NCT00302068 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 101

Last updated 2015-06-29

Study results available
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Summary

Some individuals with coronary heart disease (CHD) suffer from depression and use antidepressant medications to reduce symptoms. However, preliminary research has shown that exercise may be a more effective way to treat depression in these individuals. The purpose of this study is to evaluate the effects of exercise in reducing depression and improving heart function in individuals with CHD.

Conditions

Interventions

BEHAVIORAL

Supervised Aerobic Exercise

Supervised aerobic exercise, three times per week, for 16 weeks.

DRUG

Sertraline

Sertraline (Zoloft), daily, for 16 weeks.

DRUG

Placebo Pill.

Placebo pill, daily, for 16 weeks.

Sponsors & Collaborators

Principal Investigators

  • James A. Blumenthal, PhD · Duke University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
35 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-07-31
Primary Completion
2011-07-31
Completion
2011-12-31

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00302068 on ClinicalTrials.gov