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Role of Fibrocytes in Chronic Obstructive Pulmonary Disease

NCT01196832 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 115

Last updated 2022-02-09

No results posted yet for this study

Summary

Chronic obstructive pulmonary disease (COPD) is a frequent airway disease characterized by both bronchial inflammation and remodelling.

Bronchial mucosa is infiltrated by macrophages, neutrophils and lymphocytes. In addition, the number of eosinophils can be also increased during exacerbation.

Airway remodelling is an abnormal tissue repair following bronchial inflammation, which contributes to none reversible pathological features, such as bronchial and peri-bronchial fibrosis. It also influences the prognosis of COPD and its mechanisms remain largely unknown. The role of fibrocytes has been demonstrated in the pathophysiology of asthma, lung fibrosis or pulmonary hypertension. However, the recruitment of blood fibrocytes and their involvement in COPD airway remodelling remain unknown.

Conditions

Interventions

PROCEDURE

blood sample

blood sample for fibrocytes analysis

PROCEDURE

Clinical and functional evaluation

Plethysmography, Carbon monoxide capacity of transfer , arterial gaz

Sponsors & Collaborators

  • University Hospital, Bordeaux

    lead OTHER

Principal Investigators

  • Patrick BERGER, PUPH · University Hospital Bordeaux (France)

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-03-11
Primary Completion
2016-03-31
Completion
2016-05-31

Countries

  • France

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01196832 on ClinicalTrials.gov