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Screening for HIV-Associated Anal Cancer

NCT00188292 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 401

Last updated 2016-03-08

No results posted yet for this study

Summary

Cancer of the anus occurs at very high rates in young men with HIV and is caused by a virus called human papillomavirus (HPV). Anal cancer has increased during the HIV epidemic despite effective therapies for HIV. Unfortunately, anal cancer presents at a late stage because there is no screening program to find it at an early stage.

Rates of other cancers such as cervical cancer have been reduced through the use of Pap smears. The researchers' plan is to do the same type of screening for anal cancer as has been done for cervical cancer. If abnormalities are found then treatment can be started. The researchers hope that this approach will help to prevent anal cancer.

Testing for HPV will also be done to see if this helps to detect early cancer and to see how accurate different tests, pathologists and clinical examiners are at detecting and agreeing on any abnormalities.

The main outcome is the presence of any pre-cancerous or early cancer changes as determined by high resolution anoscopy (HRA). HRA involves looking through a microscope into the anus and this allows very tiny changes to be identified. Pieces of tissue can then be taken to make a definite diagnosis.

Conditions

  • HIV Infections
  • Anal Cancer
  • Anal Dysplasia
  • Papillomavirus Infections

Sponsors & Collaborators

  • Ontario HIV Treatment Network

    collaborator NETWORK

  • Canadian Foundation for AIDS Research (CANFAR)

    collaborator OTHER

  • University Health Network, Toronto

    lead OTHER

Principal Investigators

  • Irving E Salit, MD · Toronto General Hospital

Eligibility

Min Age
18 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2002-08-31
Primary Completion
2012-06-30
Completion
2012-06-30

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00188292 on ClinicalTrials.gov