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Leipzig Exercise Intervention in Chronic Heart Failure and Aging

NCT00176319 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2009-07-15

No results posted yet for this study

Summary

In both ageing and heart failure progressive exercise intolerance is observed. The Leipzig Exercise Intervention in Chronic heart failure and Aging (LEICA) study aims to investigate how aerobic short-term training interventions affect exercise capacity, left ventricular systolic and diastolic function, biomarkers of heart failure, skeletal muscle metabolism, and endothelial function in chronis heart failure patients (CHF-patients) and healthy subjects (HS) in two different age strata: Above 65 years and below 55 years.

Aim of the trial is therefore to compare the effects of aerobic exercise training in young and old healthy subjects as well as in young and old heart failure patients. To our knowledge this study is the first to prospectively investigate age differences of training responses in both CHF patients and age-matched healthy controls.

Because of the extensive clinical and molecular assessment the results of this trial will be made public in predefined substudies:

* LEICA-Echo
* LEICA-Biomarkers
* LEICA-Endothelium
* LEICA-Cardiopulmonary Exercise Function
* LEICA-Muscle

Conditions

Interventions

BEHAVIORAL

Aerobic endurance exercise training (ergometer)

Sponsors & Collaborators

  • German Research Foundation

    collaborator OTHER

  • University of Leipzig

    lead OTHER

Principal Investigators

  • Rainer P Hambrecht, MD · University of Leipzig, Heart Center, Dept. of Cardiology

  • Stephan Gielen, MD · University of Leipzig - Heart Center, Dept. of Internal Medicine/Cardiology

  • Volker Adams, PhD · University of Leipzig, Heart Center, Dept. of Internal Medicine/Cardiology

Study Design

Allocation
RANDOMIZED
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2005-05-31
Primary Completion
2008-12-31

Countries

  • Germany

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00176319 on ClinicalTrials.gov