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Vitamin A and Response to Endotoxin

NCT00168649 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2013-11-15

No results posted yet for this study

Summary

Vitamin A given as treatment and pre-treatment has reduced the severity of symptoms after infusion with endotoxin in several animal models. We intend to examine the effect of vitamin A as pre-treatment on the response to endotoxin in humans. We furthermore wish to examine the long-term effects of vitamin A on the response to endotoxin. We hypothesise that vitamin A decreases endotoxin levels and TNF-alfa responses.

Conditions

  • TNF-alfa
  • Endotoxin Levels

Interventions

DRUG

Vitamin A

Sponsors & Collaborators

  • Uppsala University Hospital

    collaborator OTHER

  • Institute for Human Nutrition, Royal Veterinary School, Copenhagen, Denmark

    collaborator UNKNOWN

  • Bandim Health Project

    lead OTHER

Principal Investigators

  • Bente K Pedersen, MD, DMSc · Rigshospitalet, Denmark

Study Design

Allocation
RANDOMIZED
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2005-06-30
Completion
2014-06-30

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00168649 on ClinicalTrials.gov