Evaluation of Vitamin A Absorption From Fortified Bouillon

Summary

The goal of this clinical trial is to measure how well different formulations of vitamin A (VA) are absorbed by the body when they are added to bouillon (broth) as vitamin A palmitate (VAP). Fortifying bouillon cubes with VA is one potential approach to addressing VA deficiency, which is a major public health issue in many low- and lower-income countries. The main question this study aims to answer is to compare the amount of VA that is absorbed by the body from three different VAP formulations that are added to bouillon.

Participants will consume different formulations of VA and have multiple blood collections.

Conditions

• Healthy Volunteers
• Vitamin A

Interventions

OTHER

Unfortified bouillon plus vitamin A in oil

Participants consume unfortified bouillon with vitamin A oil

OTHER

Bouillon fortified with vitamin A #1 plus unfortified oil

Participants consume vitamin A #1 fortified bouillon plus unfortified oil

OTHER

Bouillon fortified with vitamin A #2 plus unfortified oil

Participants consume vitamin A #2 fortified bouillon plus unfortified oil

Sponsors & Collaborators

• Particles for Humanity, PBC

  collaborator INDUSTRY

• Tropical Diseases Research Centre, Zambia

  collaborator OTHER_GOV

• University of Wisconsin, Madison

  lead OTHER

Principal Investigators

• Sherry Tanumihardjo, PhD · University of Wisconsin, Madison

• Bryan M Gannon, PhD · University of Wisconsin, Madison

• Luke M Funk, MD, MPH · University of Wisconsin, Madison

• Justin Chileshe, PhD · Tropical Diseases Research Centre, Zambia

Study Design

Allocation

RANDOMIZED

Purpose

OTHER

Masking

QUADRUPLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

49 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-07-10

Primary Completion

2025-11-27

Completion

2025-12-08

Countries

• United States
• Zambia

Study Locations