MedTrace Logo

Effect of Different Vitamin D Vitamers on Vitamin D Status

NCT02860663 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 14

Last updated 2016-10-28

No results posted yet for this study

Summary

Background: Dietary intake of vitamin D includes vitamin D3 (VitD3), 25-hydroxyvitamin D3 (25OHD3) and vitamin D2 (VitD2). However, the bioactivity of the different species is currently not scientifically established.

Objective: The aim of this study was to test the hypothesis that VitD3, 25OHD3 and VitD2 affected vitamin D status equally in humans and if rejected, to estimate the difference in activity.

Design: This study was designed as a 3 x 6 weeks (with 4 weeks run-in) double-blinded randomized cross-over study with 12 young, apparently healthy male volunteers and was performed during wintertime at 55 degree N. during the 4 weeks run-in period all volunteers received 10 ug/d VitD3 in order to achieve steady-state in vitamin D status. During the 3x6 weeks intervention periods the subjects received 10 ug/d VitD3, 10 ug/d 25OHD3 or 10 ug/d VitD2 in random order. Content of vitD3, VitD2, 25OHD3 and 25-hydroxyvitamin D2 (25OHD2) in serum were quantified my LC-MS/MS using 0.1 mL serum.

Conditions

  • Vitamin D Status

Interventions

DIETARY_SUPPLEMENT

Vitamin D3

10 ug/d of vitamin D3 for 6 weeks

DIETARY_SUPPLEMENT

Vitamin D2

10 ug/d of vitamin D3 for 6 weeks

DIETARY_SUPPLEMENT

25OHD

10 ug/d of vitamin D3 for 6 weeks

Sponsors & Collaborators

  • University of Copenhagen

    lead OTHER

Principal Investigators

  • Susanne Bügel · Department of Nutrition, Exercise and Sports

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2007-08-31
Primary Completion
2008-04-30
Completion
2008-04-30

Countries

  • Denmark

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02860663 on ClinicalTrials.gov