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Methods of Determining Asthma Severity in Children

NCT00132834 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2013-01-25

No results posted yet for this study

Summary

Current methods of measuring asthma severity can be problematic when used with children. A measurement called exhaled breath condensates (EBC) may be a more useful way to determine asthma severity in childhood. The purpose of this study is to determine if EBC measurements are useful for determining asthma severity in asthmatic children as compared to currently used laboratory measures.

Study hypotheses: 1) A broad panel of EBC measures will distinguish asthmatic children not on inhaled corticosteroids (ICS) from both asthmatic children routinely taking ICS and nonasthmatic controls. 2) Standardized equipment and methodologies for EBC collection, processing, storage, shipping, and pH and mediator measurements can be developed that will eliminate significant contamination from oropharyngeal saliva and allow for shipping and processing at a central site.

Conditions

Interventions

DEVICE

R-Tube or EcoScreen

Device for collection of exhaled breath condensates (EBC) collection (i.e. condensing and collecting breath vapor from a cold, solid surface)

Sponsors & Collaborators

  • National Institute of Allergy and Infectious Diseases (NIAID)

    lead NIH

Principal Investigators

  • Andrew H. Liu, MD · National Jewish Health

  • Wayne Morgan, MD, CM · University of Arizona Health Sciences Center

Eligibility

Min Age
6 Years
Max Age
17 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2003-11-30
Completion
2004-03-31

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00132834 on ClinicalTrials.gov