MedTrace Logo

Inflammatory Markers in Exhaled Breath (Condensate) in Childhood Asthma

NCT00404976 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2006-11-29

No results posted yet for this study

Summary

Background:

Exhaled nitric oxide and inflammatory biomarkers in exhaled breath condensate may be useful to diagnose and monitor childhood asthma. Their ability to indicate an asthma diagnosis, and to assess asthma severity and control, is largely unknown.

Objective:

To study 1) the ability of exhaled nitric oxide and inflammatory markers in exhaled breath condensate (nitrite, nitrate, hydrogen peroxide, 8-isoprostane, interferon-γ, tumor necrosis factor-α, interleukin-2,-4,-5,-10, acidity) to discriminate between childhood asthma and controls. 2) the ability of these biomarkers to indicate asthma severity and control.

Methods:

114 Children were included: 64 asthmatics (10.7±3.0 years, 67.2% atopic) and 50 controls (10.0±0.4 years). Condensate was collected using a glass condenser

Conditions

Sponsors & Collaborators

  • AstraZeneca

    collaborator INDUSTRY

  • Maastricht University Medical Center

    lead OTHER

Principal Investigators

  • Charlotte M Robroeks, MD · Maastricht University Medical Center

  • Edward Dompeling, MD, PhD · Maastricht University Medical Center

  • Quirijn Jöbsis, MD, PhD · Maastricht University Medical Center

Eligibility

Min Age
5 Years
Max Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2004-06-30
Completion
2005-04-30

Countries

  • Netherlands

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00404976 on ClinicalTrials.gov