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Effects of Insulin Sensitizers in Subjects With Impaired Glucose Tolerance

NCT00108615 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 48

Last updated 2008-04-25

No results posted yet for this study

Summary

Subjects with impaired glucose tolerance will be randomized to receive pioglitazone or metformin for 10 weeks. Measurements of insulin sensitivity, body composition, glucose tolerance, and muscle lipid accumulation will be performed. Adipose tissue and muscle biopsies are performed. The goal of the study is to determine whether the lipotoxiciy of impaired glucose tolerance is ameliorated by pioglitazone.

Conditions

Interventions

DRUG

Metformin

DRUG

Pioglitazone

DRUG

Metformin

DRUG

Pioglitazone

RADIATION

CT scans

To measure changes in adipose tissue volumes

PROCEDURE

Oral glucose tolerance test

To detect a change in glucose tolerance

Sponsors & Collaborators

Principal Investigators

  • Philip A Kern, MD · Central Arkansas Veterans HCS

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
35 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2004-01-31
Primary Completion
2007-04-30
Completion
2007-12-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs
Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00108615 on ClinicalTrials.gov