MedTrace Logo

Hyporeactivity and Gulf War Illness

NCT00100412 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL

Last updated 2009-01-21

No results posted yet for this study

Summary

This research project is a follow-up to the prior VA-funded study that found that chronic fatigue reported by many Gulf War veterans may be a symptom of dysfunctional cardiovascular stress response regulation. Specifically, ill veterans had diminished autonomic responses during demanding psychosocial tasks involving high level cognitive processing and emotional stress. There was a close relationship between clinical status of ill veterans and their inability to mount an appropriate physiological response under stress. The main objective of the present investigation is to determine the specific mechanism through which this abnormality may contribute to Gulf War-related chronic fatigue. We also observed that Gulf veterans with posttraumatic stress disorder (PTSD) had the most dampened autonomic activation to stressors involving higher brain activities. The second major focus of this study is to explore the role of a psychiatric disorder, specifically PTSD, as a factor in abnormalities in stress response regulation. This aspect of the study may also provide pertinent information as to the role of stress of military deployment as a contributing factor in post-Gulf War illnesses.

Conditions

  • Gulf War Syndrome
  • Chronic Fatigue Syndrome
  • Post-Traumatic Stress Disorder

Interventions

DRUG

Graded dobutamine infusions

DRUG

Graded phenylephrine injections

BEHAVIORAL

Psychosocial challenge involving socioevaluative public speaking

Sponsors & Collaborators

Study Design

Purpose
DIAGNOSTIC

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
1999-10-31
Completion
2002-09-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00100412 on ClinicalTrials.gov